Microelectrode arrays, electrosynthesis, and the optimization of signaling on an inert, stable surface

• Kendra Drayton-White,
• Siyue Liu,
• Yu-Chia Chang,
• Sakashi Uppal and
• Kevin D. Moeller

Beilstein J. Org. Chem. 2022, 18, 1488–1498, doi:10.3762/bjoc.18.156

• ; microelectrode array; Introduction Microelectrode arrays composed of collections of electrodes that can each be individually addressed are powerful platforms for monitoring interactions between a protein target and small molecules [1][2][3][4][5][6][7][8]. In these efforts, molecules are either placed or

• chemistry used to place molecules on a microelectrode array, binding events on the surface of the array are typically monitored by using the electrodes in the array to measure current changes that are caused by that event. The method is ideal in that it allows for the "real-time" detection of the binding

• -time data on binding events appear ideal for such an iterative study. However, to use a microelectrode array in this fashion requires that the molecules being synthesized be added to the surface of an array as they become available, and then the growing library analyzed in a manner that allows the

Photovoltaic-driven organic electrosynthesis and efforts toward more sustainable oxidation reactions

• Bichlien H. Nguyen,
• Robert J. Perkins,
• Jake A. Smith and
• Kevin D. Moeller

Beilstein J. Org. Chem. 2015, 11, 280–287, doi:10.3762/bjoc.11.32

• of the aromatic ring. This is a reaction that does not have a direct literature precedent on a preparative scale. Instead, it is an electrochemical reaction that was initially developed in the context of performing site-selective reactions on a microelectrode array [21]. It was selected for